Installation of -SO₂F groups onto primary amides

• Jing Liu,
• Shi-Meng Wang,
• Njud S. Alharbi and
• Hua-Li Qin

Beilstein J. Org. Chem. 2019, 15, 1907–1912, doi:10.3762/bjoc.15.186

• molecules contain pharmaceutically important amide and -SO2F moieties for application in the discovery of new therapeutics. Keywords: N-fluorosulfonyl amides; primary amides; sulfuryl fluoride (SO2F2); Introduction Sulfur(VI) fluoride exchange (SuFEx) is a new class of click chemistry developed by

• class of sulfonyl fluorides, namely, N-fluorosulfonyl amides, for the development of potential covalent inhibitors [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The Roesky group described a pioneering protocol for the synthesis of N-fluorosulfonyl amides from

• fluorosulfonyl isocyanate (Scheme 1, (2)) [36]. The available procedures for the preparation of N-fluorosulfonyl amides are very limited which relied on using either the isocyanate approach, or the amidosulfofluoride (FSO2NH2) (Scheme 1, (2)) [37][38][39]. Therefore, the development of a new method for the